STAT1 and neoplasm: We observed that 1) sensitization of tumor cells with AT-101 enhanced ATC and aATC-mediated cytotoxicity in L3.6pl, MiaPaCa-2 and CoLo-357 cells; 2) enhanced GrzB uptake of tumor cells; 3) enhanced IFN-γ induced Stat1 phosphorylation and Stat3 dephosphorylation, which in turn inhibited Bcl-XL and induced expression of pBad and Bax (Figure 14).