Since constitutive phosphorylation of Stat3 has been detected in a variety of human cancers including pancreatic tumors and PC cell lines [33], [45], [46], we examined whether ATC or aATC can induce increased apoptosis of AT-101 sensitized tumor cells via IFN-γ/Stat pathways. This evidence concerns the gene SOAT1 and pachyonychia congenita.