Since ATC and aATC treated tumor cells showed significant dephosphorylation of pY705-Stat3 and increased phosphorylation of pS727-Stat1, we next examined the effect of Stat3 dephosphorylation on its target anti-apoptotic gene Bcl-XL, and Stat1 activation on its target pro-apoptotic genes Bax and Bad. Here, STAT3 is linked to neoplasm.