YWHAQ and toxoplasmosis: Meanwhile, the 14-3-3 protein was shown to be present in the parasitophorous vacuole (PV) of T. gondii tachyzoites and was proved to be a member of excreted secreted antigens (ESA); The recombinant 14-3-3 protein was immunogenic and played a vital role in stimulating the host immune system and the 14-3-3 protein was a potential vaccine candidate against toxoplasmosis[24].