IFNG and infection: It was reported that genetically susceptible C57BL/6 mice developed necrosis of the villi and mucosal cells in small intestines following peroral infection with T. gondii and that IFN-γ-mediated pathology in the small intestine predisposes to death in these mice; In contrast, IFN-γ was required for survival in infected genetically resistant BALB/c mice[41].