Protective immunity to T. gondii is complex and involves lots of elements of the host immune system, furthermore, it is recognized that this infection in immunocompetent hosts elicits a strong Th1 type immunity response, which is characterized by the generation of parasite specific CD4+ and CD8+ T cells that produce IFN-γ and provide protective immunity against T. gondii[46,47]. This evidence concerns the gene CD8A and infection.