It was evident that, while there was no obvious interaction, both minor alleles (ABCA1 and LIPC) had statistically significant independent effects on AD risk (P = 0.005, OR = 0.405, 95%CI:0.217-0.758 and P = 0.018, OR = 0.405, 95%CI:0.191-0.858, respectively). Here, LIPC is linked to Alzheimer disease.