LIPC and Alzheimer disease: In 2008 Haiyan Zhu et al. has detected three LIPC SNPs(rs6083,rs6084 and rs6074 in coding region) in three LOAD series, and recently in a German case–control sample (438 AD patients and 290 controls) Laws SM et al. also evaluated 25 single nucleotide polymorphisms(−250 G/A not included), however, no association with AD was found[60,61].