APOA1 and Alzheimer disease: Accumulated evidence has shown that dysfunction of cholesterol metabolism may contribute to cognitive decline and AD[9], such as decreased high-density lipoprotein cholesterol (HDL-C) levels[10,11], increased low-density lipoprotein cholesterol (LDL-C) levels[4,12], and decreased apolipoproteinA-I (apoA-I) levels[11,13] known to be important risk factors for coronary atherosclerosis disease (CAD).