Some studies focused on pathological mechanism have suggested that ABCA1 mRNA expression was significantly elevated at the earliest stage of dementia, and positively correlated with neuropathological stages and neuritic plaque density counts and dementia severity, through comparison of postmortem hippocampus from persons at different stages of AD and cognitively intact normal donors by Akram A et al.[31]. Here, ABCA1 is linked to dementia.