Furthermore, implantation of mammary carcinoma 4T1 cells in IL-1 receptor-null (IL-1R-/-) mice slows tumor progression in association with immune suppression ( Bunt et al., 2007), and fibroblast growth factor receptor-1 (FGFR-1)-mediated mammary tumorigenesis is dependent on the induction of IL-1β and inhibited by administration of anti-IL-1β antibody ( Reed et al., 2009). Here, IL1B is linked to neoplasm.