p62 is a component of these inclusion bodies, which are cytoplasmic aggregates of ubiquitinated proteins commonly associated with pathological conditions, such as Alzheimer’s ( Kuusisto et al., 2002), Huntington’s ( Nagaoka et al., 2004), and Parkinson’s ( Kuusisto et al., 2001) diseases, as well as alcoholic and non-alcoholic steatohepatitis ( Zatloukal et al., 2002) and hepatocellular carcinoma ( Zatloukal et al., 2002). Here, SQSTM1 is linked to hepatocellular carcinoma.