CD40LG and neoplasm: Some of these IgM isotype, germline antibodies have been isolated from cancer patients and have proved to be able not only to recognize tumor cells, but also to kill them by different mechanisms (Bohn, 1999; Hensel et al., 2001; Jakobisiak et al., 2003; Vollmers and Brandlein, 2005, 2006; Lutz et al., 2009).