However, further investigations have shown additive and synergistic activities when used in combination therapies for the treatment of specific cancers in animal models (Bartholeyns and Koch-Weser, 1981; Marton, 1987; Quemener et al., 1992) and the potential for synthetic-lethal interactions in MYC-driven cancers specifically has yet to be directly tested. Here, MYC is linked to cancer.