ODC1 and cancer: ODC1 is a well-established oncogene in its own right (Auvinen et al., 1992), with high ODC1 activity associated with tumor growth in several human cancers, including neuroblastoma (O’Brien et al., 1975; Janne et al., 1978; Scalabrino and Ferioli, 1981; Crozat et al., 1992; Mohan et al., 1999; Wallace and Caslake, 2001; Hogarty et al., 2008).