The polyamine pathway is frequently deregulated in neuroblastoma, and a number of genes involved in polyamine homeostasis are known to be MYCN or c-MYC targets (Bello-Fernandez et al., 1993; Lutz et al., 1996; Fernandez et al., 2003; Li et al., 2003; Forshell et al., 2010), while the expression of others is linked to MYCN status (Hogarty et al., 2008; Rounbehler et al., 2009). The gene discussed is MYCN; the disease is neuroblastoma.