The meta-analysis revealed a significant association between FAS polymorphisms and SLE (rs2234767 A vs. G allele; P=0.004, OR=0.819, 95% CI, 0.715–0.938, rs1800682 G vs. A allele: P=0.034, OR=0.791, 95% CI, 0.637–0.983). This evidence concerns the gene FAS and systemic lupus erythematosus.