Among the various novel prognostic models that contain numerous promising biomarkers, including those of cellular origin (such as germinal centre B cell and activated B cell types) and immunoexpression patterns (including p53, Ki67, Bcl-2, Bcl-6, CD10 and CD5), none has achieved the required level of acceptance to be routinely used for risk stratification of DLBCL patients (12–16). The gene discussed is BCL6; the disease is diffuse large B-cell lymphoma.