In order to investigate the effect of DcR3 on gastric carcinoma cell sensitivity to chemotherapy and the possible mechanism, we observed the effect of DcR3 interference on sensitivity to 5-fluorouracil (5-FU) through transfection of various concentrations of DcR3 siRNA into gastric carcinoma AGS cells and explored the possible mechanism in view of FasL/Fas. This evidence concerns the gene TNFRSF6B and gastric carcinoma.