Investigation of the manner in which SAE supplementation reduces the epididymal fat pad weight revealed that it suppresses the expression of several proteins related to adipogenesis genes, including SREBP-1, PPARγ and FAS (Fig. 4B), indicating that it exerts an anti-obesity effect by inhibiting adipogenesis. The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.