GLO1 and major depressive disorder: In humans, genetic studies have implicated polymorphisms in GLO1 in panic disorder (Politi et al., 2006), depression (Fujimoto et al., 2008), autism (Junaid et al., 2004; Barua et al., 2011), schizophrenia (Arai et al., 2010; Toyosima et al., 2011), and restless legs syndrome (RLS) (Stefansson et al., 2007; Winkelmann et al., 2007, 2011; Kemlink et al., 2009).