In mice, several lines of evidence suggest that Glo1 expression is associated with anxiety-like behavior (Hovatta et al., 2005; Reiner-Benaim et al., 2007; Loos et al., 2009; Benton et al., 2011; Distler et al., 2012), depression (Benton et al., 2011), and neuropathic pain (Jack et al., 2011, 2012; Bierhaus et al., 2012). This evidence concerns the gene GLO1 and major depressive disorder.