For instance, it is possible that GLO1 regulates depression through its role in modulating GABAergic tone, given evidence that deficits in the GABA system have been implicated in depression (Gerner and Hare, 1981; Petty and Schlesser, 1981; Petty and Sherman, 1984; Crestani et al., 1999; Earnheart et al., 2007; Shen et al., 2010; Hasler and Northoff, 2011; Luscher et al., 2011). This evidence concerns the gene GLO1 and major depressive disorder.