Foster et al. (2012) addressed the levels of CD4+ T cells expressing IL-17 and IL-22 in 11 patients with end-stage liver disease. They noted enrichment of IL-17A, IL-17F, and IL-22 secreting populations in liver compared to blood when analyzed ex vivo, although the overall levels of production in liver derived cells were similar to those in this study. Here, IL17F is linked to End Stage Liver Disease.