In particular, the pro-apoptotic member Bim (BCL-2 interacting mediator of cell death) is known to be upregulated in sensitive ALL cells upon treatment with Dex through an indirect mechanism and plays a crucial role in apoptosis (Wang et al., 2003; Ploner et al., 2007; Chen et al., 2010). This evidence concerns the gene BCL2L11 and acute lymphoblastic leukemia.