Tumour tissues treated with MLN8237 were β-galactosidase-positive (blue) (Fig 5A), 53BP1 (red) was increased (Fig 5B, full images are in Supporting Information Fig S12), IκB-α (red) was decreased (Fig 5C) and IL-6 (red) was increased (Fig 5D). Here, IL6 is linked to neoplasm.