SET and neoplasm: To confirm that tumour suppressor roles of FTY720 requires I2PP2A/SET targeting in vivo, we generated xenografts in SCID mice using A549/shcontrol, A549/sh-I2PP2A/SET and A549/sh-I2PP2A/SET cells that express wt-I2PP2A/SET and assessed their growth with/without oral FTY720 treatment (3 mg/kg/day) compared to vehicle-treated controls.