SPHK2 and Autoimmunity: FTY720 (2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol; Fingolimod, Novartis), a synthetic sphingosine analogue of myriocin, regulates sphingosine-1-phosphate receptor signalling and suppresses autoimmunity upon its phosphorylation by sphingosine kinase-2 (SK-2) (Billich et al, 2003; Paugh et al, 2003).