Four characterized protein-coding genes within the Gct1 interval are conserved between mouse and human based on current genome annotations: Vps13d, Tnfrsf8, Tnfrsf1b, and Dhrs3. Given our hypothesis that mouse GC tumor-susceptibility candidates will provide translational information for juvenile-onset GC tumors of the ovary in young female patients, these genes have been given priority for further investigation based on sequence and expression analysis. The gene discussed is TNFRSF8; the disease is neoplasm.