Four characterized protein-coding genes within the Gct1 interval are conserved between mouse and human based on current genome annotations: Vps13d, Tnfrsf8, Tnfrsf1b, and Dhrs3. Given our hypothesis that mouse GC tumor-susceptibility candidates will provide translational information for juvenile-onset GC tumors of the ovary in young female patients, these genes have been given priority for further investigation based on sequence and expression analysis. This evidence concerns the gene VPS13D and ovarian neoplasm.