A Japanese case–control study has nicely shown that several biomarkers of ischemia-induced angiogenesis or oxidative stress, including angiotensin, vascular endothelial growth factor, oxidized low density lipoprotein, and circulating EPC (CD34+CD133+CD202b+CD45−), were increased in the OSA group and decreased after nasal CPAP treatment [28]. The gene discussed is PROM1; the disease is obstructive sleep apnea syndrome.