On the other hand, neither the amount of 24 hr urinary excreted Klotho nor the serum soluble Klotho levels correlated with several parameters, including not only FGF23 and calcium found in the serum but also with the amount of urinary excreted sodium, calcium, potassium, and phosphorus (data not shown), suggesting that the intrinsic role of the soluble Klotho on the disruption of mineral metabolism associated with various degrees of CKD might be marginal[14,28]. The gene discussed is FGF23; the disease is chronic kidney disease.