KL and chronic kidney disease: The random urine Klotho/Cr did not trend towards lower values with advancing stages of CKD (overall p = 0.058) (Figure4a); however, the random urine Klotho/Cr, as well as the amount of 24 hr urinary excreted Klotho, correlated inversely with the stages of CKD (Spearman’s rho value = −0.234, p < 0.01).