A nonsynonymous sequence variation (rs738409) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) that substitutes methionine for isoleucine at residue 148 (I148M) was first reported to be associated with hepatic triglyceride content in a genome-wide screen [11]; subsequently its association with NAFLD was confirmed in multiple ethnic and geographic groups (for a review see [14]) including the East Asian populations [15-19]. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.