Furthermore, Gupta et al. used EMT-induced breast cancer stem cells in the screening that discovered salinomycin; breast cancer cells having undergone shRNA-mediated knock-down of E-cadherin expression displayed an increased proportion of CD44high/CD24low cells, increased resistance to chemotherapeutic drugs, and enhanced sensitivity to salinomycin [5]. This evidence concerns the gene CDH1 and breast carcinoma.