Meindl et al. [9,25] and Osorio et al. [16] state that RAD51C mutations predispose to breast and ovarian cancer whereas Loveday et al. [17] estimated the relative risk of ovarian cancer for RAD51C protein truncating mutation carriers to be 5.88 but no elevated risk for breast cancer. The gene discussed is RAD51C; the disease is breast carcinoma.