Further, several studies have shown that the ability of the GnRH/GnRHR system to reduce cell tumor invasion and metastatic potential are associated with up regulation of actin cytoskeleton remodeling, mainly through the activation of Rac1 [22,23] as well as by influencing the activity of cell-cell adhesion molecules and/or the regulation of cell substrate attachment-associated proteins [24,25]. This evidence concerns the gene GNRHR and neoplasm.