This effect was reversed by anti-IL-21R antibodies in both RA patients (41.65% ± 3.00% vs. 52.82% ± 4.03% vs. 46.50% ± 2.72%, P < 0.05; Figure 5a) and HC (28.87% ± 3.66% vs. 38.12% ± 2.66% vs. 33.13% ± 3.59%, P < 0.05; Figure 5a). Here, IL21R is linked to rheumatoid arthritis.