The employment of the wrapper algorithm has pinpointed the following features for each classification algorithm: BN: ecog status, cholesterol, grade differentiation and N staging; NB: allergies, cholesterol, depth invasion, lympphoplasmacytic rection and N staging; ANN: ecog status, cholesterol, depth of invasion and N staging; SVM: ecog status, smoking duration and N staging; DT: depth of invasion, p16ink4a stain and N staging; RF: quantity of cigarettes, galvanic current, eating habits, BMI, depth invasion and N staging. Here, CDKN2A is linked to allergic disease.