NR1I3 and AIDS: Previously characterised SNPs in NR1I3 include NR1I3 rs2307424C>T, of which the rs2307424T allele has been associated with low efavirenz plasma concentrations and the NR1I3 rs2307424C/C genotype has been associated with early discontinuation of efavirenz-containing anti-retroviral therapy (ART) in Caucasian HIV/AIDS patients[13].