The trend in EQ-5Dindex across CKD stages evaluated with Spearman’s partial correlation was ρ= −0.18 (p<0.01; pooled sample) , ρ= −0.20 (p<0.01; UK sample) , ρ= −0.18 (p<0.01; US sample) after adjustment for age, gender, center of enrollment, diabetes, cardiovascular diseases, anxiety or depression, hypertension, ALT, AST, months since transplant. The gene discussed is GPT; the disease is depressive symptom measurement.