IFNL3 and cryohydrocytosis: In this line different literature data showed that naive G1 CHC patients without severe hepatic fibrosis and with IL28B CC genotype have a likelihood of SVR greater than 80% when treated with DT, being similar high rates of SVR also observed in patients achieving a rapid virological response (RVR) (5% of patients with IL28B TT/TC, and 30% of patients with IL28B CC), regardless of the IL28B genotype [10].