In our study the primary screen using cytokine microarray analysis on pooled samples yielded 12 cytokines differentially regulated in PSP/CBS, MSA, PD and controls (GRO, ICAM-1, IL-2 R-alpha, IL-6 R, leptin, MCP-4, NAP-2, PDGF-BB, prolactin, RANTES, TIMP-2 and TRAIL R3). This evidence concerns the gene LEP and multiple system atrophy.