Il6 was also up-regulated selectively in the Amela melanomas (Table 1), in agreement with high level detection of Il-6 in Amela tumor supernatant and serum of Amela-bearing mice [11] and with previous reports on its induction by oncogenic Ras in different cell types [34], including melanomas in a distinct model of H-rasG12V-induced melanoma in mice [35]. This evidence concerns the gene IL6 and melanoma.