At CDKAL1, we evaluated the association of rs4712523, which showed the strongest association in our previous GWA study of type 2 diabetes [5], with BMI and found reproducible evidence for association in 2 independent panels (Table 3), where the risk allele (G of rs4712523) for type 2 diabetes showed nominal association with lower BMI [P = 0.024 in the Amagasaki panel (n = 5,695) and P = 0.02 in the Fukuoka panel (n = 12,569)]. Here, CDKAL1 is linked to type 2 diabetes mellitus.