Corresponding to this enhanced increase in osteoclast numbers, a reduction in bone volume over total tissue volume (BV/TV) was observed in mice coinjected with both tumor cells and tumor-induced Gr-1+/CD11b+cells compared to mice inoculated tumor cells alone (Fig. 4C, 2.72±0.34% vs. 3.07% ±0.26%), although the difference between the two groups was not statistically significant at the late time point examined. Here, ITGAM is linked to neoplasm.