When cancer cells grow in bone in MM or cancer-bone metastasized condition, they initiate a “vicious cycle” by secreting growth factors and cytokines to induce osteoclast differentiation and excessive bone resorption that in turn leads to an increase the production of growth factors, such as transforming growth factor beta (TGFβ), to stimulate tumor growth in bone [14], [15]. This evidence concerns the gene TGFB1 and neoplasm.