A small but statistically significant acceleration in the development of paraplegia was observed in mice that received both 5TGM1 and myeloma-associated Gr-1+/CD11b+cells compared to mice that received 5TMG1 alone (Fig. 4F, 29.4 (±1.02) vs. 26.8 (±1.5) days post inoculation, n = 5, p = 0.02). This evidence concerns the gene ITGAM and paraplegia.