Nuclear localization of E-cadherin has been predominantly observed in pituitary adenomas [53], esophageal squamous cell carcinoma [54], Merkel cell carcinoma [55], solid pseudopapillary tumor of the pancreas [56], [57], clear-cell renal cell carcinoma [58], colorectal cancer (and its liver metastases) [54] and ovarian granulosa cell tumors [59]. The gene discussed is CDH1; the disease is esophageal squamous cell carcinoma.