Metastasis to the lung, liver and kidney demonstrated that the dormant tumor cells within the bone marrow that formed primary tumors in the mammary fat pad retained a similar metastatic profile as the “parental” cells within the tumorspheres; however the expression patterns of E-cadherin and β-catenin within the metastatic lesions in the lung and liver derived from DTC-derived tumors differed from the lesions in the lung and liver derived from tumorsphere-derived tumors [25]. The gene discussed is CDH1; the disease is neoplasm.