Considering that LRMP is known to be expressed in germinal centre B-cells and in diffuse large B-cell Lymphomas of the “germinal” center subtype [12], we hypothesize that regulatory elements originally located upstream of the LRMP gene and juxtaposed to the MYC-locus, might be involved in the de-regulation of MYC. Interestingly, a recent report shows a case of a primary B-cell lymphoma with a t(8;12) translocation also involving MYC and LRMP[13]. This evidence concerns the gene MYC and diffuse large B-cell lymphoma.