In our study, we showed that initial and ∆ CRP levels were not as valuable for predicting ICU mortality in sepsis patients and 3rd day control CRP was better than initial CRP values and ∆ CRP values, respectively (3rd day CRP AUC: 0.72, CI: 0.63-0.80; initial CRP AUC: 0.57, CI: 0.48-0.66; ∆ CRP AUC: 0.41, CI: 0.30-0.50). The gene discussed is CRP; the disease is Sepsis.