TP53 and infection: The data showed that there was no detectable cytotoxicity in HCT-116 and GES-1 cells infected with Ad315-E1A or H101 (10 PFU/cell), whereas Ad315-E1A infection achieved significant growth inhibition of the IGF2 LOI and p53-active cell line (HCT-8) relative to that by H101 infection.