The LOI-targeting oncolytic adenoviral vector Ad315-E1A induced cytopathic effects as efficiently as that of the oncolytic adenovirus H101 in the LOI and p53-inactive cell line (HT-29), whereas the growth inhibition ability of H101 was more strongly attenuated in the wild-type p53 and LOI cancer cell line (HCT-8) (p > 0.05). This evidence concerns the gene TP53 and cancer.