PTPN22 and autoimmune disease: Inhibitors of PTPN22 are currently being developed by various research groups and pharmaceutical companies as potential therapeutic agents for the treatment of multiple autoimmune diseases.106 The main challenge with the development of these compounds is related to their insufficient selectivity and cell permeability, but recent progress in the field suggests that clinically useful compounds may become available for testing in CLL and PTPN22-associated autoimmune diseases in the near future.107,108