BCR and B-cell chronic lymphocytic leukemia: The mechanism that generates the elevated basal BCR signaling activity in CLL cells was only very recently revealed.31 In their seminal paper, Dühren-von Minden et al investigated a large series of CLL BCRs (n=17) and showed that all of them are capable of inducing an autonomous signal when introduced in a B cell line that does not express a functional BCR.