For example, the cell autonomous BCR signal does not seem to result in full SYK activation, considering that phosphorylation of the activation loop tyrosines (YY525/526) of SYK is usually not detected in unstimulated CLL cells, whereas it is readily detected in most CLL samples stimulated with anti-IgM antibodies, which are used to mimic external antigen32. Here, SYK is linked to B-cell chronic lymphocytic leukemia.