BTK and B-cell chronic lymphocytic leukemia: For example, BTK and ABL are also inhibited by Dasatinib, and both of these molecules appear to be important for CLL cell survival.64–66 Silencing of LYN by RNA interference should clarify this issue, but so far this approach has not proven very effective presumably because of the significant overexpression and long half-life of LYN in CLL cells.18,67