IFNG and anemia (phenotype): STAT6, a member of signal transducer and activator of transcription family proteins, seems also to be involved in malarial anaemia through the activation of the regulatory cytokines, in particular IL-4 and IFN-γ, resulting in erythropoietic suppression during blood stage malaria.51,52 A recent review found an interesting correlation between malarial anaemia and micronutrient malnutrition: vitamin A and E, iron, zinc, riboflavin and folate deficiency may play a role in worsening the anaemia mediated by alteration of immunity, dyserythropoiesis and iron metabolism 39.