VWF and Thrombocytopenia: In contrast, another study demonstrated that sGP1b, the external domain of platelet receptor for VWF, increased early in the blood of malaria patients thus preventing excessive platelet adhesion.60 Despite thrombocytopenia is very common, hemorrhagic events are rare and usually are associated with severe thrombocytopenia or disseminated intravascular coagulation (DIC).61–63 Further study are needed to understand the relationship between malaria, platelet counts and hemorrhagic events.