PML and viral infectious disease: More importantly, another report has described that LCMV multiplication in PML −/− murine embryonic fibroblasts (MEF) exceeds virus production in PML +/+ MEF [116], and that in vivo PML deficiency renders mice more susceptible to different viral infections, such as vesicular stomatitis virus, encephalomyocarditis virus and LCMV infection, resulting in an increased viral replication [144,145].