Similarly, a comparison of the nuclear proteome in NPC cells with and without EBNA expression showed that EBNA1 upregulated several oxidative stress response proteins including the antioxidants superoxide dismutase 1 (SOD1) and peroxiredoxin 1 (Prx1), that can be induced in response to ROS [62]. This evidence concerns the gene PRDX1 and nasopharyngeal carcinoma.