PTPRC and anthrax infection: Following the discovery that compounds that inhibit the tyrosine phosphatase CD45 prevent apoptosis of macrophages infected with Bacillus anthracis, and that transgenic mice expressing low levels of CD45 are partially protected from anthrax infection in vivo [62], it was found that transgenic mice expressing low levels of CD45 were solidly resistant to maEBOV infection [63].