CASP8 and cancer: The meta-analysis results showed that the del allele, del allele carrier and ins/del genotypes of −652 6N ins/del in CASP-8 gene were negatively associated with cancer risk (OR=0.91, 95% CI=0.84–0.98, P=0.01; OR=0.88, 95% CI=0.80–0.96, P=0.005; OR=0.91, 95% CI=0.85–0.98, P<0.001; respectively) (Figs. 2–4), while no significant correlation was observed between the del/del genotypes of −652 6N ins/del and cancer risk (OR=0.89, 95% CI=0.79–1.01, P=0.08).