MAPT and early-onset autosomal dominant Alzheimer disease: These include β-amyloid (Aβ) peptides in the neuritic plaques of Alzheimer’s disease (AD), the fibrillation of tau protein to form neurofibrillary tangles in AD and Pick bodies in frontotemporal dementia (FTD), and alpha-synuclein in the Lewy bodies of Parkinson disease (PD) and in Lewy body disease [1,2].