The 47 exons of the sequenced genes PIK3R1 (p85α subunit of PI3K), PIK3CA (catalytic subunit of PI3K) FRAP1 (mTOR), the three AKT isoforms (AKT1, AKT2, AKT3) and the genetic alterations identified within the 10 HCC samples are summarized in Table 1. The gene discussed is PIK3R1; the disease is hepatocellular carcinoma.