INS and myeloid sarcoma: Adipose tissue is a major endocrine organ, secreting substances such as adiponectin, leptin, resistin, tumor necrosis factor α, interleukin 6, and plasminogen activator inhibitor-1 that may play a critical role in the pathogenesis of the MS.103 Visceral (intra-abdominal) adipose tissue (VAT) compared to total body fat correlates significantly better with triglycerides, systolic and diastolic BP, and is expected to decrease the sensitivity of target tissues to insulin.104,105