Disturbances in glucose and insulin metabolism may not be a normal characteristic of aging, but rather associated with obesity and physical inactivity.131 Recent evidence from the Emerging Risk Factors Collaboration demonstrates that glucose levels exceeding 100 mg/dL are a key risk factor for life expectancy.132 Lifestyle change, including PA and weight loss, is the central strategy in T2D prevention. The gene discussed is INS; the disease is type 2 diabetes mellitus.