Although only few studies have examined the efficacy of different modes of exercise in the reversal of the clinical diagnosis of MS,99 numerous studies and systematic reviews have reported the benefits of AET or RT on components of MS, such as abdominal obesity, BP, blood lipids, and insulin resistance.100–102 The following part focuses on supervised exercise training studies for the purpose of determining the role of PA on changes in MS risk factors among obese individuals. This evidence concerns the gene INS and myeloid sarcoma.