In contrast to previously described AMD mouse models involving lipid metabolism such as ApoE−/−, CD36−/−, SR-BI−/−, LDLR−/− mice [14], [35], [36], [37], [38], [39], Fatp1-deficient mice did not show drusen and oil red O labeling or abnormal lipofuscin accumulation. The gene discussed is APOE; the disease is age-related macular degeneration.