The sensitivity analysis comparing macrovascular disease plus angina in premix insulin versus basal analogue after two OGLDs had a hazard ratio of 1.49 and a lower 95% confidence interval of 0.99 although the same comparison after three oral agents did not show a difference in risk between the insulins with a hazard ratio of 0.76 (95% confidence interval 0.39, 1.51). This evidence concerns the gene INS and angina pectoris.