EGFR and neoplasm: Furthermore, the mutual functional compensation of family members [48], the modulation of activity by expression and intracellular distribution of their respective ligands [49], [50] as well as by signaling pathways such as EGF-R signaling [51] and additional functions such as the recently described involvement of EVL in homologous recombinational repair of double-strand DNA breaks [52], may all have significant and sometimes opposite impact on tumor cell development and progression.