INS and obesity due to melanocortin 4 receptor deficiency: Interestingly, fish oil (FO) derived long chain n-3 polyunsaturated fatty acids (PUFA), specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been shown to favorably impact obesity-associated pathologies, including adipose tissue inflammation, insulin resistance, lipid metabolism and hepatic steatosis [4], [5], [6], [7], [8], [9], [10], [11], [12].