To gain insight into how effector T cell populations are changing in the context of concurrent obesity and colitis, the expression of critical transcription factors associated with specific T cell subsets in the colonic scraped mucosa, i.e., FOXP3 (Tregs), Tbet (Th1 cells) and RORγτ (Th17 cells) and critical cytokines that influence T cell polarization and function were assessed. Here, TBX21 is linked to obesity disorder.