The epidermal growth factor receptor (EGFR/ErbB1), a member of the ErbB family of receptor tyrosine kinases, is amplified or over-active in many types of epithelial cancers, including pancreatic cancer, breast cancer, brain cancer, non-small cell lung cancer, colorectal cancer, breast and head and neck squamous-cell carcinoma [1], [2], [3]. Here, EGFR is linked to familial pancreatic carcinoma.