TRIM63 and Cachexia: At 54 weeks of aged, immediately before the observed beginning of weight loss in the initial experiment, we examined parameters associated with cachexia, such as muscle weight and the expression of cachexia-associated genes in muscles, such as those coding for the muscle-specific ubiquitin ligases MuRF1 (Trim63) [27] and Atrogin-1 (Fbxo32) [28] (Figure 5E–F).